SHERMAN OAKS (CBSLA.com) — A multi-vehicle injury crash shut down the northbound 405 Freeway in Sherman Oaks early Monday morning.

The six-vehicle accident was reported shortly after 1:45 a.m. at Sepulveda Boulevard just south of the 101 Freeway, according to the California Highway Patrol.

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Officials shut down all lanes after one person was ejected and another was trapped. Two lanes were reopened around 3 a.m. and the SigAlert was canceled opening up all lanes just after 5:20 a.m.

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At least four people were transported to local hospitals with major injuries.

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The cause of the crash was unknown.