SAN DIEGO ( — A state-wide Amber Alert has been issued for two children from San Diego County after the remains of their mother and another child were found in a burned-out house.

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Hannah Anderson, 16, and her 8-year-old brother, Ethan, were last seen Saturday around 5 p.m. in Boulevard, approximately 60 miles east of San Diego near the Mexican border, the San Diego County Sheriff’s Department said.

Authorities believe the two children are with James Lee DiMaggio, who is suspected of killing their mother, 44-year-old Christina Anderson, along with an unidentified child and a dog.

The two victims were discovered Sunday night in the rubble of DiMaggio’s burning Boulevard home, according to authorities.

DiMaggio and Anderson are said to have had a close platonic relationship. He is now wanted for murder and arson.

“We need the public’s help in locating these people,” Lt. Glenn Giannantorio said. “We would definitely like to locate the children. We believe that if they are with Mr. DiMaggio, that they in danger.”

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The Amber Alert was issued after the children’s grandparents reported them missing.

Hannah is described as having blonde hair and blue eyes. She is 5 feet 7 inches tall and weighs about 115 pounds.

Ethan is described as 4 feet 11 inches tall, weighing about 65 pounds with sandy blonde hair.

DiMaggio, 40, is described as a White male with brown hair, 5 feet 9 inches tall and weighing about 150 pounds.

Authorities believe DiMaggio may be driving a four-door, 2013 Blue Nissan Versa with the California license plate number 6WCU986. They believe he may be headed to Texas or Canada.

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Anyone who sees DiMaggio or the children should call 911 immediately.