The house is located in the 19000 block of Vanowen.
The Red Cross is assisting those affected by the blast, reported at 15025 Vanowen Street, according to LAFD spokesperson Brian Humphrey.
Police were looking for the driver of a pick-up truck who hit two teenagers in a Van Nuys intersection on Tuesday.
A suspect was in custody Friday morning after a man and woman were shot in Van Nuys.
A search is underway Sunday for an arsonist who may be responsible for setting at least 14 car, mobile home and apartment fires in North Hollywood over the last two days.
Police have identified the man who was fatally shot while driving through Van Nuys Friday.