California Highway Patrol officers say the victim was driving a 2007 GMC and collided with a 2006 Kenworth tractor/trailer near Ventura Boulevard at 12:55 a.m.
The crash involved several vehicles, according to the CHP.
The Border Patrol says its agents have found more than nine tons of marijuana worth an estimated $14.7 million when they inspected a truck at the San Clemente checkpoint.
Police said seven children, ranging in ages from six months to 8 years old, were injured when a van from their daycare center collided with a tractor-trailer in Ontario.
Police Friday confiscated $5 million worth of cocaine that was found stashed in a big rig truck during a San Fernando Valley drug bust.
A street race that led to a crash in South Los Angeles left two people with major injuries early Saturday morning, the California Highway Patrol said.
Authorities say an SUV carrying two people crashed into a tractor trailer in Sunland Friday afternoon trapping both people.
A man who investigators believe was sleeping on a curb in Lake Elsinore was seriously injured when he was run over by a tractor trailer.