The closure will take place Saturday from 1 a.m. to 6 a.m. and Sunday from midnight to 6 a.m. Monday from Getty Center Drive to Santa Monica Boulevard, Metro said.
All lanes of the I-405 Freeway in the Sepulveda Pass will be closed Saturday night for construction work.
A collision between two big rigs Tuesday evening caused a traffic jam and spilled gallons of milk on the southbound 5 Freeway in Valenica.
The southbound 405 Freeway shut down through the Sepulveda Pass Monday night as crews worked to build the second half of the Mulholland Drive bridge.
Several people were injured in six accidents on the Hollywood (101) Freeway Friday morning.
Caltrans is advising motorists to avoid parts of the northbound 710 Freeway Monday morning.