Both vehicles were doing about 60 mph at the time of the crash, according to a police report cited by People.
One of the victims was ejected from a vehicle.
The crash — east of Palmdale — was reported just after 7:45 p.m. at 165th Street and Avenue S.
A CHP pursuit of a suspect on a motorcycle ended horrifically Sunday when the cyclist crashed head-on into a vehicle.
Investigators Friday were still trying to determine the factors behind a head-on collision in Tustin that left two motorists dead.
Authorities on Saturday continued to investigate the circumstances surrounding a deadly hit-and-run crash in Mid City.
Three people were killed and six more suffered major injuries in a head-on collision in Redlands Thursday morning, according to authorities.
Authorities say a 31-year-old man was killed Saturday evening following a head-on crash in Torrance.
A major surgery wasn’t going to keep Kalin Mathews from going ahead with her plans to wed the father of her 6-week-old baby.
One person died and two others were taken to trauma centers in critical condition following a head-on collision in Garden Grove Wednesday.
One person is dead and another injured after a head-on collision in Moreno Valley Friday.
A woman was killed Friday evening after the car she was driving slammed head-on into oncoming traffic in Anaheim.