Crews were called to the scene at 4390 East Valley Boulevard, adjacent to the Metrolink railroad tracks just east of Soto Avenue, and several blocks from the County/USC Medical Center, around 11:30 a.m.
The Lake Fire reportedly had grown to 17,405 acres and was 30 percent contained as of 6 a.m. Tuesday.
Authorities said about 1,900 firefighters were working around the clock to battle the blaze.
The fire — burning on the 8300 block of N. Willis — has engulfed at least six cars.
The blaze located near 160th Street West and Lancaster Road was initially reported around 1:50 p.m. Friday, according to the Los Angeles County Fire Department.
The residents — two adults and three children — are looking for a new home.
Firefighters were on the roof where flames were clearly visible.
One person is dead and another seriously injured in an apartment fire in Woodland Hills Saturday evening.
The terrain is inaccessible by ground units, officials said.
The building is located at Cedros and Nordhoff, authorities said.
There are no reports of injuries.
No injuries were reported at the famous film studio.
Crews were called to the 200 block of 88th Place, near San Pedro Street, at 8:21 p.m. but quickly put out the blaze.
The first was burning near the intersection of Grove and Chino Avenue.
The complex was to be home to 1,500 new condos.